Category: Sober Living

The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of…

Start patients with renal impairment on one-fourth to one-half the usual starting dose depending on the degree of impairment. Patients with renal impairment should be closely monitored during dose titration see CLINICAL PHARMACOLOGY. Maternal toxicity (decreased food consumption and body weight gain) was also noted at the two highest doses tested. Opioids cross the placenta…